diff --git a/src/reader.rs b/src/reader.rs
index 5067ccbba..098323c43 100644
--- a/src/reader.rs
+++ b/src/reader.rs
@@ -243,7 +243,11 @@ pub(crate) fn initial_query(
     vars: Option<&dyn Environment>,
 ) {
     blocking_query.get_or_init(|| {
-        let query = if is_dumb() || IN_MIDNIGHT_COMMANDER.load() || IN_DVTM.load() {
+        let query = if is_dumb()
+            || IN_MIDNIGHT_COMMANDER.load()
+            || IN_DVTM.load()
+            || !isatty(STDOUT_FILENO)
+        {
             None
         } else {
             // Query for kitty keyboard protocol support.
@@ -1525,6 +1529,9 @@ pub(crate) fn blocking_query(&self) -> RefMut<'_, Option<TerminalQuery>> {
     }
 
     pub fn request_cursor_position(&mut self, out: &mut Outputter, q: CursorPositionQuery) {
+        if !isatty(STDOUT_FILENO) {
+            return;
+        }
         let mut query = self.blocking_query();
         assert!(query.is_none());
         *query = Some(TerminalQuery::CursorPositionReport(q));
diff --git a/tests/checks/tmux-invocation.fish b/tests/checks/tmux-invocation.fish
new file mode 100644
index 000000000..01100371d
--- /dev/null
+++ b/tests/checks/tmux-invocation.fish
@@ -0,0 +1,20 @@
+#RUN: %fish %s
+#REQUIRES: command -v tmux
+
+set -g isolated_tmux_fish_extra_args -C '
+    set -g fish (status fish-path)
+'
+isolated-tmux-start
+
+# Implicit interactive but output is redirected.
+isolated-tmux send-keys \
+    '$fish >output' Enter
+tmux-sleep
+isolated-tmux send-keys \
+    'status is-interactive && printf %s i n t e r a c t i v e \n' Enter \
+    C-d
+tmux-sleep
+# Extract the line where command output starts.
+string match <output -r '.*\e\]133;C.*' |
+string escape
+# CHECK: {{.*}}interactive{{$}}